Whilst updating Boot scripts today, I noticed I was turning LCDGameModes off in the Lotus Turbo Challenge 2 script. From a previous conversation with Jeffrey, I think this was done to stop the game hanging, due to the critical timing the game requires. Might be worth using it as a test for any future updates.
I also came across a game that was shifted way off to the left, although can't for the life of me remember which, Drifter possibly. I had to turn LCDGameModes off for it as well.
EDIT: It was Sensible Soccer, not Drifter that's shifted off to the left.